CCK (27-33) (non-sulfated) (Synonyms: Cholecystokinin (27-33) (non-sulfated)) |
Katalog-Nr.GC18384 |
CCK (27-33) is a C-terminal fragment of CCK , a peptide hormone found in the intestine and brain that stimulates digestion, mediates satiety, and is involved in anxiety.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 47910-79-2
Sample solution is provided at 25 µL, 10mM.
CCK (27-33) is a C-terminal fragment of CCK , a peptide hormone found in the intestine and brain that stimulates digestion, mediates satiety, and is involved in anxiety. Non-sulfated CCK (27-33) inhibits binding of [3H]naloxone in rat cerebellum membranes (IC50 = 4 uM) and inhibits electrically-stimulated contraction of isolated guinea pig ileum (IC50 = 17 uM), an effect that can be reversed by naloxone. Unlike sulfated CCK (27-33), the non-sulfated form does not reduce exploratory behavior in mice when administered at doses up to 1 uMol/kg.
References:
[1]. Raybould, H.E., and Lloyd, K.C. Integration of postprandial function in the proximal gastrointestinal tract. Role of CCK and sensory pathways Ann. N.Y. Acad. Sci. 713(1), 143-156 (1994).
[2]. Ondetti, M.A., Plu??ec, J., Sabo, E.F., et al. Synthesis of cholecystokinin-pancreozymin. I. The C-terminal dodecapeptide J. Am. Chem. Soc. 92(1), 195-199 (1970).
[3]. Schiller, P.W., Lipton, A., Horrobin, D.F., et al. Unsulfated C-terminal 7-peptide of cholecystokinin: A new ligand of the opiate receptor Biochem. Biophys. Res. Commun. 85(4), 1332-1338 (1978).
[4]. Crawley, J.N., St-Pierre, S., and Gaudreau, P. Analysis of the behavioral activity of C- and N-terminal fragments of cholecystokinin octapeptide J. Pharmacol. Exp. Ther. 230(2), 438-444 (1984).
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