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CCT373566 (Synonyms: CCT373566; CCT 373566; CCT-373566;)

Katalog-Nr.GB62229 Copy One-Click Copy Product Info

CCT373566 is a highly potent BCL6 degrader (IC50 =0.

Products are for research use only. Not for human use. We do not sell to patients.

CCT373566 Chemische Struktur

Cas No.: 2378853-66-6

Größe Preis Lagerbestand Menge
1mg
150,00 $
Auf Lager
5mg
550,00 $
Auf Lager
10mg
950,00 $
Auf Lager
25mg
1.650,00 $
Auf Lager
50mg
2.950,00 $
Auf Lager

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Kundenbewertungen

Basiert auf Kundenrezensionen.

Sample solution is provided at 25 µL, 10mM.



Description of CCT373566

CCT373566 is a highly potent BCL6 degrader (IC50 =0.7 nM) suitable for sustained depletion of BCL6 in vivo. CCT373566 showed modest in vivo efficacy in a lymphoma xenograft mouse model following oral dosing. The transcriptional repressor BCL6 is an oncogenic driver found to be deregulated in lymphoid malignancies.

Chemical Properties of CCT373566

Cas No. 2378853-66-6 SDF
Überlieferungen CCT373566; CCT 373566; CCT-373566;
Canonical SMILES CN(C1=C(C2=C3OCC(F)(F)[C@H](C4CC4)N2)C=C(NC5=NC(N6C[C@H](O)C[C@H](C)C6)=NC=C5Cl)C=C1)C3=O
Formula C26H29ClF2N6O3 M.Wt 547.0038
Löslichkeit To be determined Storage Store at-20℃
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of CCT373566

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 1.8281 mL 9.1407 mL 18.2814 mL
5 mM 365.6 μL 1.8281 mL 3.6563 mL
10 mM 182.8 μL 914.1 μL 1.8281 mL
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In vivo Formulation Calculator (Clear solution) of CCT373566

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Product Documents

Quality Control & SDS

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Review for CCT373566

Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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