CDK4-IN-1-d6 |
| Katalog-Nr.GC62894 |
CDK4-IN-1-d6 ist ein mit Deuterium beschriftetes CDK4-IN-1. CDK4-IN-1 (Verbindung 63) ist ein CDK4-Inhibitor (IC50 = 10 nM).
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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CDK4-IN-1-d6 is a deuterium labeled CDK4-IN-1. CDK4-IN-1 (compound 63) is a CDK4 inhibitor (IC50= 10 nM)[1].
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process[1].
[1]. Cho YS, Borland M, Brain C, et al. 4-(Pyrazol-4-yl)-pyrimidines as selective inhibitors of cyclin-dependent kinase 4/6. J Med Chem. 2010;53(22):7938-7957.
[2]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
Average Rating: 5 (Based on Reviews and 27 reference(s) in Google Scholar.)
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