Cinnabarinic acid |
| Katalog-Nr.GC12705 |
CinnabarinsÄure ist ein spezifischer orthosterischer Agonist von mGlu4, indem sie mit Resten der Glutamat-Bindungstasche von mGlu4 interagiert und keine AktivitÄt an anderen mGlu-Rezeptoren hat.
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Cas No.: 606-59-7
Sample solution is provided at 25 µL, 10mM.
Cinnabarinic acid is a phenoxazinone produced by the oxidative dimerization of 3-hydroxyanthranilic acid (3-HAA) as part of the metabolism of tryptophan in the kynurenic pathway.[1],[2] It acts as a partial receptor agonist of the metabotropic glutamate receptor 4 (mGlu4), effective at 100 µM, with no activity at other mGlu receptor subtypes.[3] 3-HAA does not affect mGlu receptors, including mGlu4. Cinnabarinic acid induces apoptosis of T cells at 300-500 µM, a potency some ten times that of 3-HAA.[4]
Reference:
[1]. Subba Rao, P.V., and Vaidyanathan, C.S. Enzymic conversion of 3-hydroxyanthranilic acid into cinnabarinic acid. Partial purification and properties of rat-liver cinnabarinate synthase. Biochemistry Journal 99(2), 317-322 (1966).
[2]. Stone, T.W., Stoy, N., and Darlington, L.G. An expanding range of targets for kynurenine metabolites of tryptophan. Trends in Pharamacological Sciences 34(2), 136-143 (2013).
[3]. Fazio, F., Lionetto, L., Molinaro, G., et al. Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology 81(5), 643-656 (2012).
[4]. Hiramatsu, R., Hara, T., Akimoto, H., et al. Cinnabarinic acid generated from 3-hydroxyanthranilic acid strongly induces apoptosis in thymocytes through the generation of reactive oxygen species and the induction of caspase. Journal of Cellular Biochemistry 103(1), 42-53 (2008).
| Cas No. | 606-59-7 | SDF | |
| Chemical Name | 2-amino-3-oxo-3H-phenoxazine-1,9-dicarboxylic acid | ||
| Canonical SMILES | O=C1C(N)=C(C(O)=O)C2=NC3=C(C(O)=O)C=CC=C3OC2=C1 | ||
| Formula | C14H8N2O6 | M.Wt | 300.22 |
| Löslichkeit | DMSO: 25 mM (warmed) | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 3.3309 mL | 16.6545 mL | 33.3089 mL |
| 5 mM | 666.2 μL | 3.3309 mL | 6.6618 mL |
| 10 mM | 333.1 μL | 1.6654 mL | 3.3309 mL |
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Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
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- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 3 reference(s) in Google Scholar.)
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