Citropten (Synonyms: 5,7-Dimethoxycoumarin) |
| Katalog-Nr.GC46121 |
Citropten (5,7-Dimethoxycumarin) ist ein aus BergamotteÖl isoliertes Cumarin. Citropten (5,7-Dimethoxycumarin) hat eine antiproliferative Wirkung gegen die menschliche Melanom-Zelllinie A2058.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 487-06-9
Sample solution is provided at 25 µL, 10mM.
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Citropten is a coumarin that has been found in bergamot extracts and has diverse biological activities.1,2,3,4 It reduces IL-8 mRNA accumulation induced by TNF-α or heat-inactivated P. aeruginosa in IB3-1 cells derived from cystic fibrosis patients.1 Citropten induces cell cycle arrest at the G1 phase and inhibits proliferation of A375, MCF-7, PC3, and SW620 cancer cells (IC50s = 250-325 μM).2 It is active against various Gram-positive and Gram-negative bacteria (MICs = 16-64 μg/ml).3 Citropten increases prothrombin time in isolated rat platelet-poor plasma. In vivo, citropten (10 mg/kg) prevents decreases in locomotor activity and increases in hippocampal monoamine oxidase A (MAO-A) levels in a rat model of chronic mild stress-induced depression.4
|1. Borgatti, M., Mancini, I., Bianchi, N., et al. Bergamot (Citrus bergamia Risso) fruit extracts and identified components alter expression of interleukin 8 gene in cystic fibrosis bronchial epithelial cell lines. BMC Biochem. 12, 15 (2011).|2. Alesiani, D., Cicconi, R., Mattei, M., et al. Cell cycle arrest and differentiation induction by 5,7-dimethoxycoumarin in melanoma cell lines. Int. J. Oncol. 32(2), 425-434 (2008).|3. Rosselli, S., Maggio, A., Bellone, G., et al. Antibacterial and anticoagulant activities of coumarins isolated from the flowers of Magydaris tomentosa. Planta Med. 73(2), 116-120 (2006).|4. Yang, W., and Wang, H. 5,7-Dimethoxycoumarin prevents chronic mild stress induced depression in rats through increase in the expression of heat shock protein-70 and inhibition of monoamine oxidase-A levels. Saudi J. Biol. Sci. 25(2), 253-258 (2018).
| Cas No. | 487-06-9 | SDF | |
| Überlieferungen | 5,7-Dimethoxycoumarin | ||
| Canonical SMILES | O=C1C=CC2=C(OC)C=C(OC)C=C2O1 | ||
| Formula | C11H10O4 | M.Wt | 206.2 |
| Löslichkeit | DMF: 25 mg/ml,DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml,DMSO: 14 mg/ml,Ethanol: 3 mg/ml | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 4.8497 mL | 24.2483 mL | 48.4966 mL |
| 5 mM | 969.9 μL | 4.8497 mL | 9.6993 mL |
| 10 mM | 485 μL | 2.4248 mL | 4.8497 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 38 reference(s) in Google Scholar.)
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