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CMP3a (Synonyms: CMP3a; CMP-3a; CMP 3a.)

Katalog-Nr.GB62206 Copy One-Click Copy Product Info

CMP3a is a NEK2 kinase inhibitor.

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CMP3a Chemische Struktur

Cas No.: 2225902-88-3

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5mg
350,00 $
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10mg
550,00 $
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25mg
1.150,00 $
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50mg
2.050,00 $
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Sample solution is provided at 25 µL, 10mM.



Description of CMP3a

CMP3a is a NEK2 kinase inhibitor. CMP3a efficiently attenuated GBM growth in a mouse model and exhibited a synergistic effect with radiotherapy. Targeting NEK2 attenuates glioblastoma growth and radioresistance by destabilizing histone methyltransferase EZH2.

Chemical Properties of CMP3a

Cas No. 2225902-88-3 SDF
Überlieferungen CMP3a; CMP-3a; CMP 3a.
Canonical SMILES O=C(C1=C(O[C@@H](C2=CC=CC=C2C(F)(F)F)C)C=C(C3=CN=C4C=C(C5=CN(CCN(C)C)N=C5)C=CN43)S1)N
Formula C28H27F3N6O2S M.Wt 568.6192
Löslichkeit Soluble in DMSO Storage Store at-20℃
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of CMP3a

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 1.7586 mL 8.7932 mL 17.5865 mL
5 mM 351.7 μL 1.7586 mL 3.5173 mL
10 mM 175.9 μL 879.3 μL 1.7586 mL
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In vivo Formulation Calculator (Clear solution) of CMP3a

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Product Documents

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Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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