Colchicoside (Synonyms: 3-Demethylcolchicine glucoside) |
Katalog-Nr.GC47118
One-Click Copy Product Info
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A glycoside form of 3-demethylcolchicine
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 477-29-2
Sample solution is provided at 25 µL, 10mM.
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Colchicoside is a glycoside form of 3-demethylcolchicine that has been found in G. superba.1 Unlike cholchicine and 3-demethylcolchicine, colchicoside does not displace [3H]-colchicine from rat brain tubulin in vitro when used at a concentration of 25 μM.2 Colchicoside (1 and 10 μM) increases levels of the cytochrome P450 (CYP) isoforms CYP2C9 and CYP2E1 in primary human hepatocytes.3
1.Capistrano, I.R., Vangestel, C., Vanpachtenbeke, H., et al.Coadministration of a Gloriosa superba extract improves the in vivo antitumoural activity of gemcitabine in a murine pancreatic tumour modePhytomedicine23(12)1434-1440(2016) 2.Sugio, K., Maruyama, M., Tsurufuji, S., et al.Separation of tubulin-binding and anti-inflammatory activity in colchicine analogs and congenersLife Sci.40(1)35-39(1987) 3.DvorÁk, Z., UlrichovÁ, J., ModrianskÝ, M., et al.Effect of colchicine and its derivatives on the expression of selected isoforms of cytochrome P450 in primary cultures of human hepatocytesActa Univ. Palacki. Olomuc. Fac. Med.14347-50(2000)
| Cas No. | 477-29-2 | SDF | |
| Überlieferungen | 3-Demethylcolchicine glucoside | ||
| Canonical SMILES | O[C@H]([C@H]1O)[C@H](O)[C@@H](CO)O[C@H]1OC2=CC3=C(C(C([C@@H](NC(C)=O)CC3)=C4)=CC=C(OC)C4=O)C(OC)=C2OC | ||
| Formula | C27H33NO11 | M.Wt | 547.6 |
| Löslichkeit | DMF: 30 mg/ml,DMSO: 30 mg/ml,PBS (pH 7.2): 10 mg/ml | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 1.8262 mL | 9.1308 mL | 18.2615 mL |
| 5 mM | 365.2 μL | 1.8262 mL | 3.6523 mL |
| 10 mM | 182.6 μL | 913.1 μL | 1.8262 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 7 reference(s) in Google Scholar.)