(D)-PPA 1 (trifluoroacetate salt) (Synonyms: DPPA-1, NYSKPTDRQYHF) |
| Katalog-Nr.GC52442 |
An inhibitor of the PD-1-PD-L1 protein-protein interaction
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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(D)-PPA 1 is an inhibitor of the protein-protein interaction between programmed cell death protein 1 (PD-1) and PD-1 ligand (PD-L1).1 It binds to the extracellular domain of PD-L1 (Kd = 0.51 µM for the recombinant human protein). (D)-PPA 1 (2 mg/kg) decreases tumor volume and improves survival in a CT26 murine colorectal cancer model.
1.Chang, H.-N., Liu, B.-Y., Qi, Y.-K., et al.Blocking of the PD-1/PD-L1 interaction by a D-peptide antagonist for cancer immunotherapyAngew. Chem. Int. Ed. Engl.54(40)11760-11764(2015)
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