Demecarium Bromide (BC-48) |
| Katalog-Nr.GC31190 |
Demecariumbromid (BC-48) (BC-48) ist ein potenter Cholinesterasehemmer mit einer scheinbaren AffinitÄt (Kiapp) von 0,15 μM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 56-94-0
Sample solution is provided at 25 µL, 10mM.
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Demecarium Bromide (BC-48) is a potent cholinesterase antagonist, with an apparent affinity (Kiapp) of 0.15 μM[1]. Demecarium Bromide (BC-48) is used as a glaucoma agent[2].
Demecarium Bromide (0.125 and 0.5%) causes long-term miosis and decreases intraocular pressure (IOP) in beagles with both normotensive eyes and inherited glaucoma[1].
[1]. Brown JH, et al. Activation and blockade of cardiac muscarinic receptors by endogenous acetylcholine and cholinesterase inhibitors. J Pharmacol Exp Ther. 1982 Oct;223(1):20-4. [2]. Gum GG, et al. Effect of topically applied demecarium bromide and echothiophate iodide on intraocular pressure and pupil size in beagles with normotensive eyes and beagles with inherited glaucoma. Am J Vet Res. 1993 Feb;54(2):287-93.
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