DL-Mevalonolactone (Synonyms: DL-Mevalonic Acid Lactone, (±)-Mevalonolactone, NSC 90804) |
| Katalog-Nr.GC40495 |
DL-Mevalonolacton ((±)-Mevalonolacton; Mevalolacton) ist die δ-Lacton-Form von MevalonsÄure, einem VorlÄufer im Mevalonat-Weg.
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Cas No.: 674-26-0
Sample solution is provided at 25 µL, 10mM.
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DL-Mevalonolactone ((±)-Mevalonolactone;Mevalolactone) is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway. DL-Mevalonolactone (Mevalonolactone) decreases mitochondrial membrane potential (∆Ψm), NAD(P)H content and the capacity to retain Ca2+ in the brain, besides inducing mitochondrial swelling[1][2].
References:
[1]. Domingos SR, et al. On the structural intricacies of a metabolic precursor: Direct spectroscopic detection of water-induced conformational reshaping of mevalonolactone. J Chem Phys. 2017 Sep 28;147(12):124310.
[2]. Cecatto C, et al. Mevalonolactone disrupts mitochondrial functions and induces permeability transition pore opening in rat brain mitochondria: Implications for the pathogenesis of mevalonic aciduria. Neurochem Int. 2017 Sep;108:133-145.
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