Eplivanserin hemifumarate |
| Katalog-Nr.GC50084 |
Eplivanserin (SR-46349) Hemifumarat ist ein potenter, selektiver und oral aktiver 5-HT2A-Rezeptorantagonist mit einem IC50-Wert von 5,8 nM in der kortikalen Rattenmembran und einem Kd von 1,14 nM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 130580-02-8
Sample solution is provided at 25 µL, 10mM.
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Potent and selective 5-HT2A antagonist (IC50 values are 5.8 and 120 and >100 nM for 5-HT2A, 5-HT2B and 5-HT2C, respectively). Attenuates cocaine-induced hyperactivity. Increases dopamine (DA) release in rat medial prefrontal cortex (mPFC); potentiates haloperidol-induced DA release in the mPFC and nucleus accumbens.
Yadav et al (2011) Antagonist functional selectivity: 5-HT2A serotonin receptor antagonists differentially regulate 5-HT2A receptor protein level in vivo. J.Pharmacol.Exp.Ther. 339 99 PMID:21737536 |Filip et al (2004) Contribution of serotonin (5-hydroxytryptamine; 5-HT) 5-HT2 receptor subtypes to the hyperlocomotor effects of cocaine: acute and chronic pharmacological analyses. J.Pharmacol.Exp.Ther. 310 1246 PMID:15131246 |Bonaccorso et al (2002) SR46349-B, a 5-HT(2A/2C) receptor antagonist, potentiates haloperidol-induced DA release in rat medial prefrontal cortex and nucleus accumbens. Neuropsychopharmacology. 27 430 PMID:12225700
Average Rating: 5 (Based on Reviews and 26 reference(s) in Google Scholar.)
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