Toosendanin (Synonyms: Chuanliansu, 28-Deacetylsendanin) |
| Katalog-Nr.GC38417 |
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 58812-37-6
Sample solution is provided at 25 µL, 10mM.
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Toosendanin, a triterpenoid extracted from the bark of fruit of Melia toosendan Sieb et Zucc, possesses analgesic, insecticidal and anti-inflammatory activities[1].
Toosendanin (0.5 and 1 mg/kg, Intraperitoneal injection daily for 7 days) alleviates DSS-induced experimental colitis by inhibiting M1 macrophage polarization and regulating NLRP3 inflammasome and Nrf2/HO-1 signaling, and may provide a novel Chinese patent medicine for the treatment of murine colitis[1]. Animal Model: Forty-eight male C57BL/6 mice weighing 20-22 g[1].
[1]. Fan H, et al. Toosendanin alleviates dextran sulfate sodium-induced colitis by inhibiting M1 macrophage polarization and regulating NLRP3 inflammasome and Nrf2/HO-1 signaling. Int Immunopharmacol. 2019 Sep 11;76:105909.
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