GDC-0276 |
| Katalog-Nr.GC39559 |
GDC-0276 ist ein potenter, selektiver, reversibler und oral aktiver NaV1.7-Inhibitor mit einem IC50-Wert von 0,4 nM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1494581-70-2
Sample solution is provided at 25 µL, 10mM.
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GDC-0276 is a potent, selective, reversible and orally active NaV1.7 inhibitor with an IC50 value of 0.4 nM. GDC-0276 is well tolerated and exhibits a good pharmacokinetic profile. GDC-0276 has the potential for the treatment of pain and to address shortcomings of existing pain medications, such as addiction and off-target side effects[1].
[1]. Rothenberg ME, et al. Safety, Tolerability, and Pharmacokinetics of GDC-0276, a Novel NaV1.7 Inhibitor, in a First-in-Human, Single- and Multiple-Dose Study i [2]. Steven J. McKerrall, et al. Nav1.7 inhibitors for the treatment of chronic pain. Bioorganic & Medicinal Chemistry Letters (2018) [3]. Takahashi RH,et al.Unequal Absorption of Radiolabeled and Nonradiolabeled Drug from the Oral Dose Leads to Incorrect Estimates of Drug Absorption and Circulating Metabolites in a Mass Balance Study.Drug Metab Lett. 2019;13(1):37-44.
Average Rating: 5 (Based on Reviews and 31 reference(s) in Google Scholar.)
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