GNE-618 |
| Katalog-Nr.GC39624 |
GNE-618 ist ein potenter, oral aktiver Nicotinamid-Phosphoribosyl-Transferase (NAMPT)-Inhibitor mit einem IC50 von 6 nM. GNE-618 senkt den NAD-Spiegel und induziert den Tod von Tumorzellen. Anti-Tumor-AktivitÄt.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1362151-42-5
Sample solution is provided at 25 µL, 10mM.
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GNE-618 is a potent, orally active nicotinamide phosphoribosyl transferase (NAMPT) inhibitor with an IC50 of 6 nM. GNE-618 depletes NAD levels and induces tumor cell death. Anti-tumor activity[1].
[1]. Xiao Y, et al. Dependence of tumor cell lines and patient-derived tumors on the NAD salvage pathway rendersthem sensitive to NAMPT inhibition with GNE-618. Neoplasia. 2013 Oct;15(10):1151-60.
Average Rating: 5 (Based on Reviews and 4 reference(s) in Google Scholar.)
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