GSK256073 |
| Katalog-Nr.GC39651 |
GSK256073 ist ein potenter, selektiver und oral aktiver GPR109A-Agonist und ein langanhaltender und nicht errÖtender HCA2-Vollagonist mit einem pEC50 von 7,5 (humanes HCA2).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 862892-90-8
Sample solution is provided at 25 µL, 10mM.
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GSK256073 is a potent, selective and orally active GPR109A agonist and a long-lasting and non-flushing HCA2 full agonist with a pEC50 of 7.5 (human HCA2). GSK256073 acutely improves glucose homeostasis via inhibition of lipolysis and has the potential for the study of type 2 diabetes mellitus (T2DM)and dyslipidemia[1][2]. GPR109A: G-protein coupled receptor 109A; HCA2: hydroxy-carboxylic acid receptor 2
[1]. Dobbins RL, et al. GSK256073, a selective agonist of G-protein coupled receptor 109A (GPR109A) reduces serum glucose in subjects with type 2 diabetes mellitus.Diabetes Obes Metab. 2013 Nov;15(11):1013-21. [2]. Sprecher D, et al. Discovery and characterization of GSK256073, a non-flushing hydroxy-carboxylic acid receptor 2 (HCA2) agonist.Eur J Pharmacol. 2015 Jun 5;756:1-7.
Average Rating: 5 (Based on Reviews and 27 reference(s) in Google Scholar.)
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