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Guanoclor (Synonyms: Guanochlor)

Katalog-Nr.GC45678

Guanoclor (Vatensol) ist ein Dopamin-Beta-Hydroxylase (DBH)-Hemmer, der die Noradrenalin-Synthese stÖrt.

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Guanoclor Chemische Struktur

Cas No.: 5001-32-1

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5mg
101,00 $
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10mg
161,00 $
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25mg
378,00 $
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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents Related Products

Guanoclor is an antihypertensive agent that binds to non-adrenergic sites in pig kidney membranes (IC50 = 10 nM).1,2 It inhibits the Na+/H+ exchanger in pig kidney membranes (IC50 = 1 μM) and cell-free bovine dopamine β-hydroxylase (IC50 = 90 μM). Guanoclor inhibits electrically stimulated norepinephrine release from spleen.1 It decreases norepinephrine levels in dog heart, spleen, hypothalamus, and adrenal gland when administered at a dose of 10 mg/kg per day for six weeks. It decreases adrenal catecholamine levels in rats when administered at a dose of 20 mg/kg per day for six weeks. Guanoclor (20 mg/kg) decreases experimentally induced hypertension and the tyramine-induced pressor response and increases the norepinephrine-induced pressor response in non-anesthetized dogs.

|1. Lawrie, T.D., Lorimer, A.R., McAlpine, S.G., et al. Clinical trial and pharmacological study of compound 1029. ("Vatensol"). Br. Med. J. 1(5380), 402-406 (1964).|2. Vigne, P., Lazdunski, M., and Frelin, C. Guanabenz, guanochlor, guanoxan and idazoxan bind with high affinity to non-adrenergic sites in pig kidney membranes. Eur. J. Pharmacol. 160(2), 295-298 (1989).

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