Hydroxy Bosentan (Synonyms: Ro 48-5033, Ro 48-8634) |
| Katalog-Nr.GC43876 |
Hydroxybosentan (Ro 48-5033) ist ein primÄrer Metabolit von Bosentan (BOS), der durch das Cytochrom-P450-System in der Leber metabolisiert wird.
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Cas No.: 253688-60-7
Sample solution is provided at 25 µL, 10mM.
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Hydroxy bosentan is an active phase I metabolite of bosentan produced by the cytochrome P450 isoforms CYP3A4 and CYP2C9. Bosentan is an antagonist of the endothelin receptors type A (Ki = 6.5 nM) and type B (Ki = 340 nM). Up to 20% of the activity of bosentan may be due to the action of hydroxy bosentan because even though it has a lower affinity for endothelin receptors, its concentration is 3-fold higher in plasma.
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