Irisolidone |
| Katalog-Nr.GC63514 |
Irisolidon ist ein wichtiges Isoflavon, das in Pueraria lobata-BlÜten vorkommt.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2345-17-7
Sample solution is provided at 25 µL, 10mM.
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Irisolidone is a major isoflavone found in Pueraria lobata flowers. Irisolidone exhibits potent hepatoprotective activity. Irisolidone shows the high efficacy for volume-regulated anion channels (VRAC) blockade[1][2][3].
Irisolidone shows the high efficacy for Volume-regulated anion channels (VRAC) blockade with an IC50 of 9.8 μM in HEK293 cells[3].Irisolidone can inhibit endothelial cell proliferation[3].
[1]. Kim SY, et al. Irisolidone, an isoflavone metabolite, represses JC virus gene expression via inhibition of Sp1 binding in human glial cells. Biochem Biophys Res Commun. 2006 May 26;344(1):3-8.
[2]. Zhang G, et al. Pharmacokinetics of irisolidone and its main metabolites in rat plasma determined by ultra performance liquid chromatography/quadrupole time-of-flight mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Nov 15;1005:23-9.
[3]. Xue Y, et al. Natural and synthetic flavonoids, novel blockers of the volume-regulated anion channels, inhibit endothelial cell proliferation. Pflugers Arch. 2018 Oct;470(10):1473-1483.
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