JCN037 (Synonyms: JGK037) |
| Katalog-Nr.GC39750 |
JCN037 (JGK037) ist ein nicht-kovalenter und BBB-penetranter EGFR-Tyrosinkinase-Inhibitor mit IC50-Werten von 2,49 nM, 3,95 nM, 4,48 nM fÜr EGFR, p-wtEGFR bzw. pEGFRvⅢ.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2305154-31-6
Sample solution is provided at 25 µL, 10mM.
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JCN037 (JGK037) is potent, non-covalent and brain-penetrant EGFR tyrosine kinase inhibitor, with IC50 values of 2.49 nM, 3.95 nM, 4.48 nM for EGFR, p-wtEGFR and pEGFRvⅢ, respectively[1].
[1]. Jonathan E. Tsang, et al. Development of a Potent Brain-Penetrant EGFR Tyrosine Kinase Inhibitor against Malignant Brain Tumors. ACS Med. Chem. Lett. 2020. May 1.
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