K6PC-5 |
Katalog-Nr.GC49155
One-Click Copy Product Info
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K6PC-5, ein synthetisches Ceramid-Derivat, ist ein direkter Aktivator der Sphingosinkinase 1 (SPHK1) und lÖst einen raschen vorÜbergehenden Anstieg des intrazellulÄren Calciumspiegels aus.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 756875-51-1
Sample solution is provided at 25 µL, 10mM.
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K6PC-5 is a sphingosine kinase 1 (SPHK1) activator.1,2,3 It activates SPHK1 in F9-12 teratocarcinoma cell lysates and isolated murine blood in a concentration-dependent manner.1 K6PC-5 (25 and 50 µM) induces calcium oscillations in HaCaT keratinocytes. It inhibits cell death induced by oxygen-glucose deprivation/reoxygenation in SH-SY5Y neuroblastoma cells when used at a concentration of 10 µM.2 Topical administration of K6PC-5 (1%) increases stratum corneum integrity and corneodesmosome density in a mouse model of photoaging induced by long-term exposure to ultraviolet A (UVA) and UVB radiation.3
1.Hong, J.H., Youm, J.K., Kwon, M.J., et al.K6PC-5, a direct activator of sphingosine kinase 1, promotes epidermal differentiation through intracellular Ca2+ signalingJ. Invest. Dermatol.1282166-2178(2008) 2.Liu, H., Zhang, Z., Xu, M., et al.K6PC-5 activates SphK1-Nrf2 signaling to protect neuronal cells from oxygen glucose deprivation/re-oxygenationCell Physiol. Biochem.51(4)1908-1920(2018) 3.Park, H.-y., Youm, J.-K., Kwon, M.J., et al.K6PC-5, a novel sphingosine kinase activator, improves long-term ultraviolet light-exposed aged murine skinExp. Dermatol.17(1)829-836(2008)
| Cas No. | 756875-51-1 | SDF | |
| Canonical SMILES | O=C(C(CCCCCC)C(CCCCCCC)=O)NC(CO)CO | ||
| Formula | C19H37NO4 | M.Wt | 343.5 |
| Löslichkeit | DMSO: 30 mg/ml | Storage | -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.9112 mL | 14.556 mL | 29.1121 mL |
| 5 mM | 582.2 μL | 2.9112 mL | 5.8224 mL |
| 10 mM | 291.1 μL | 1.4556 mL | 2.9112 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 10 reference(s) in Google Scholar.)