KMH-233 |
| Katalog-Nr.GC61845 |
KMH-233, ein potenter, reversibler und selektiver Inhibitor des AminosÄuretransporters 1 (LAT1) vom L-Typ, hemmt die Aufnahme des LAT1-Substrats L-Leucin (IC50=18 μM) sowie das Zellwachstum. KMH-233 potenziert die Wirksamkeit von Bestatin und Cisplatin sogar bei niedrigen Konzentrationen (25 μM).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1941174-13-5
Sample solution is provided at 25 µL, 10mM.
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KMH-233, a potent, reversible and selective l-type amino acid transporter 1 (LAT1) inhibitor, inhibits the uptake of LAT1 substrate, l-leucin (IC50=18 µM) as well as cell growth. KMH-233 significantly potentiates the efficacy of Bestatin and Cisplatin even at low concentrations (25 µM)[1].
KMH-233 is able to inhibit binding and transport of essential neutral amino acids and thus, inhibit the cell growth of cancer cells[1].KMH-233 shows a significant reduction of cell growth with an IC50 of 124 µM[1].KMH-233 is effective and able to potentiate the anti-proliferative efficacy of Bestatin (100 µM) and Cisplatin (100 µM) at a lower concentration of 25 µM, inhibiting cell growth 53% and 50%, respectively[1].
References:
[1]. Huttunen KM, et al. A Selective and Slowly Reversible Inhibitor of l-Type Amino Acid Transporter 1 (LAT1) Potentiates Antiproliferative Drug Efficacy in Cancer Cells. J Med Chem. 2016;59(12):5740-5751.
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