Lenalidomide-acetylene-C5-COOH (Synonyms: Cereblon ligand-linker Conjugate) |
| Katalog-Nr.GC60983 |
Lenalidomid-Acetylen-C5-COOH (Verbindung 43; Cereblon-Ligand-Linker-Konjugat) ist der auf Lenalidomid basierende Cereblon-Ligand, der zur Rekrutierung des CRBN-Proteins verwendet wird. Lenalidomid-Acetylen-C5-COOH kann mit dem Liganden fÜr Protein durch einen Linker verbunden werden, um PROTAC zu bilden.
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Cas No.: 2429878-72-6
Sample solution is provided at 25 µL, 10mM.
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Lenalidomide-acetylene-C5-COOH (compound 43; Cereblon ligand-linker Conjugate) is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-acetylene-C5-COOH can be connected to the ligand for protein by a linker to form PROTAC[1].
[1]. Bai L, et al. A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo. Cancer Cell. 2019 Nov 11;36(5):498-511.e17.
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