Methylspinazarin (Synonyms: Methylspinazaline) |
| Katalog-Nr.GC46170 |
A bacterial metabolite and COMT inhibitor
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 41768-12-1
Sample solution is provided at 25 µL, 10mM.
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Methylspinazarin is a naphthoquinone bacterial metabolite that has been found in Streptomyces and is an inhibitor of catechol O-methyltransferase (COMT; IC50 = 0.8 μg/ml).1 It is selective for COMT over tyrosine hydroxylase, DOPA decarboxylase, and dopamine-β-hydroxylase at 100 μg/ml. Methylspinazarin decreases blood pressure in spontaneously hypertensive rats when administered at a dose of 50 mg/kg.
|1. Chimura, H., Sawa, T., Takita, T., et al. Methylspinazarin and dihydromethylspinazarin, gatechol-O-methyl transerfase inhibitors produced by Streptomyces. J. Antibiot. 26(2), 112-114 (1973).
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