mGluR2 antagonist 1 |
| Katalog-Nr.GC61061 |
mGluR2-Antagonist 1 ist eine hochwirksame, oral bioverfÜgbare und selektive Klasse von negativen allosterischen mGluR2-Modulatoren (IC50 von 9 nM) mit ausgezeichneter GehirnpermeabilitÄt.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1432728-49-8
Sample solution is provided at 25 µL, 10mM.
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mGluR2 antagonist 1 is a highly potent, orally bioavailable and selective class of mGluR2 negative allosteric modulator (IC50 of 9 nM) with excellent brain permeability[1].
In vivo, mGluR2 antagonist 1 (Compound 25) reverses the effect of mGluR2 agonist LY379268 in amphetamine-induced hyperlocomotion and shows good efficacy in the mouse delayed non-match to position assay at 10 mg/kg.
[1]. Youheng Shu,et al. Discovery of 4-arylquinoline-2-carboxamides, Highly Potent and Selective Class of mGluR2 Negative Allosteric Modulators: From HTS to Activity in Animal Models. Bioorg Med Chem Lett. 2020 May 1;30(9):127066.
Average Rating: 5 (Based on Reviews and 22 reference(s) in Google Scholar.)
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