Miravirsen (Synonyms: SPC-3649) |
| Katalog-Nr.GC64487 |
Miravirsen (SPC-3649), ein β-d-Oxy-verriegeltes NukleinsÄure-modifiziertes Phosphorothioat-Antisense-Oligonukleotid, hemmt die Biogenese von miR-122.
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Cas No.: 1072874-90-8
Sample solution is provided at 25 µL, 10mM.
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Miravirsen (SPC-3649), a β-d-oxy-locked nucleic acid-modified phosphorothioate antisense oligonucleotide, inhibit the biogenesis of miR-122. Miravirsen (SPC-3649) is used in the study for HCV infections[1].
Miravirsen is thought to work mainly by hybridizing to mature miR-122 and blocking its interaction with HCV RNA, its target sequence is also present in pri- and pre-miR-122[1]. Miravirsen binds to the stem-loop structure of pri- and pre-miR-122 with nanomolar affinity, and inhibits both Dicer- and Drosha-mediated processing of miR-122 precursors[1].
[1]. Luca F R Gebert, et al. Miravirsen (SPC3649) can inhibit the biogenesis of miR-122. Nucleic Acids Res. 2014 Jan;42(1):609-21.
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