MLS000532223 |
| Katalog-Nr.GC61076 |
MLS000532223 ist ein hochaffiner, selektiver Inhibitor von GTPasen der Rho-Familie mit EC50-Werten im Bereich von 16 μM bis 120 μM. MLS000532223 verhindert die GTP-Bindung an mehrere GTPasen.
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Cas No.: 16616-39-0
Sample solution is provided at 25 µL, 10mM.
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MLS000532223 is a high affinity, selective inhibitor of Rho family GTPases, with EC50 ranging from 16 μM to 120 μM. MLS000532223 prevents GTP binding to several GTPases. Small GTPases are key regulators of cellular activity [1].
MLS000532223 prevents GTP binding to several GTPases in a dose-dependent manner[1].MLS000532223 modulates Rho-family GTP-binding kinetics[1].MLS000532223 is active in cell-based assays and inhibits EGF-stimulated Rac 1 activation[1].MLS000532223 inhibits actin rearrangements and changes in cell morphology that are downstream of Rho family GTPase activation[1].MLS000532223 (10 μM) modulates actin remodeling in mast cells[1].MLS000532223 (10 μM) inhibits ligand-stimulated β-hexosaminidase secretion of RBL cells[1].
[1]. Zurab Surviladze, et al. Identification of a Small GTPase Inhibitor Using a High-Throughput Flow Cytometry Bead-Based Multiplex Assay. J Biomol Screen. 2010 Jan;15(1):10-20.
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