Mulberrin (Kuwanon C) (Synonyms: Mulberrin) |
Katalog-Nr.GC32597 |
Mulberrin (Kuwanon C) ist ein starker Inhibitor der durch das organische Anionen transportierenden Polypeptid 2B1 (OATP2B1) vermittelten Östron-3-sulfat (E3S)-Aufnahme mit einem IC50-Wert von 1,81,5 μM.
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Cas No.: 62949-79-5
Sample solution is provided at 25 µL, 10mM.
Mulberrin is a strong inhibitor of organic anion-transporting polypeptide 2B1 (OATP2B1)-mediated estrone-3-sulfate (E3S) uptake with an IC50 value being 1.8 ±1.5 μM.
Mulberrin is a flavone with two isopentenyl groups at positions 3 and 8. Mulberrin is a strong inhibitor of OATP2B1 with more than 80% inhibition.Mulberrin also inhibits organic anion-transporting polypeptide (OATP)-mediated uptake of Atorvastatin, Fluvastatin, and Rosuvastatin[1].
[1]. Wen F, et al. Identification of natural products as modulators of OATP2B1 using LC-MS/MS to quantify OATP-mediated uptake. Pharm Biol. 2016;54(2):293-302.
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