NCGC00379308 (Synonyms: (D3-βArr;NCGC-00379308;NCGC 00379308)) |
| Katalog-Nr.GC19543 |
NCGC00379308 ist ein positiver allosterischer Modulator fÜr den Thyrotropin-Rezeptor (TSHR), der die Translokation von β-Arr 1 durch direkte TSHR-Aktivierung initiiert und die TSH-vermittelte PrÄosteoblasten-Differenzierung in vitro potenziert.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 662164-09-2
Sample solution is provided at 25 µL, 10mM.
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A potent, functionally selective TSH receptor (TSHR) positive allosteric modulator with EC50 of 11.6 uM (β-Arr 1 translocation); does not activate β-Arr 1 translocation to the GLP1R, binds and activates the TSHR and has no agonistic effect on cAMP production nor inhibit TSH-induced cAMP production in DiscoverX1 cells and primary cultures of human thyrocytes; potentiates TSH-induced upregulation of ALPL and OPN mRNA levels, and increases TSH-induced secretion of OPN protein; potentiates the effect of TSH to enhance differentiation of a human preosteoblast in an in vitro model
Reference:
[1]. Neumann S, et al. J Pharmacol Exp Ther. 2018 Jan;364(1):38-45..
| Cas No. | 662164-09-2 | SDF | |
| Überlieferungen | (D3-βArr;NCGC-00379308;NCGC 00379308) | ||
| Chemical Name | N-(1-phenylethyl)-2-(1-piperazinyl)-4-quinazolinamine | ||
| Formula | C20H23N5 | M.Wt | 333.439 |
| Löslichkeit | DMSO : ≥ 125 mg/mL (374.89 mM) | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.999 mL | 14.9952 mL | 29.9905 mL |
| 5 mM | 0.5998 mL | 2.999 mL | 5.9981 mL |
| 10 mM | 0.2999 mL | 1.4995 mL | 2.999 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
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Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 22 reference(s) in Google Scholar.)
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