NoxA1ds |
| Katalog-Nr.GC50281 |
NoxA1ds ist ein hochwirksamer und selektiver Nox1-Hemmer (NADPH-Oxidase-Isoform 1).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1435893-78-9
Sample solution is provided at 25 µL, 10mM.
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Potent and selective NADPH oxidase 1 (NOX1) inhibitor (IC50 = 20 nM). Exhibits selectivity for NOX1 over NOX2, NOX4, NOX5 and xanthine oxidase. Inhibits NOX1-derived O2- production in HT-29 human colon cancer cells. Attenuates VEGF-induced human pulmonary artery endothelial cell migration under hypoxic conditions in vitro. Cell permeable.
Ranayhossaini et al (2013) Selective recapitulation of conserved and nonconserved regions of putative NOXA1 protein activation domain confers isoform-specific inhibition of Nox1 oxidase and attenuation of endothelial cell migration. J.Biol.Chem. 288 36437 PMID:24187133
Average Rating: 5 (Based on Reviews and 8 reference(s) in Google Scholar.)
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