OB-1 (Synonyms: Stomatin-like Protein 3 Inhibitor OB-1) |
| Katalog-Nr.GC50492 |
Stomatin-like protein-3 (STOML3) oligomerization inhibitor
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 300803-69-4
Sample solution is provided at 25 µL, 10mM.
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Stomatin-like protein-3 (STOML3) oligomerization inhibitor. Reduces STOML3 cluster size in the plasma membrane. Decreases mechanically-induced Piezo1 but not ASIC3 current amplitudes in N2a cells and cultured mouse sensory neurons in vitro. Subcutaneous administration in mice reversibly silences touch receptor activity and inhibits paw withdrawal reflex in a mouse neuropathic pain model.
Wetzel et al (2017) Small-molecule inhibition of STOML3 oligomerization reverses pathological mechanical hypersensitivity. Nat.Neurosci. 20 209 PMID:27941788
Average Rating: 5 (Based on Reviews and 11 reference(s) in Google Scholar.)
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