OBI-3424 (Synonyms: TH-3424) |
| Katalog-Nr.GC62501 |
OBI-3424 (TH-3424) ist ein Prodrug, das selektiv von AKR1C3 (Aldo-Keto-Reduktase 1C3) in ein wirksames DNA-alkylierendes Mittel umgewandelt wird. OBI-3424 kann in der Forschung zu hepatozellulÄrem Karzinom, kastrationsresistentem Prostatakrebs und akuter lymphoblastischer LeukÄmie (ALL) eingesetzt werden.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2097713-68-1
Sample solution is provided at 25 µL, 10mM.
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OBI-3424 (TH-3424) is a prodrug that is selectively converted by AKR1C3 (aldo-keto reductase 1C3) to a potent DNA-alkylating agent. OBI-3424 can be used for hepatocellular carcinoma, castrate-resistant prostate cancer, and acute lymphoblastic leukemia (ALL) research[1].
OBI-3424 exerts potent cytotoxicity against the H460 lung cancer cell line (IC50 of 4.0 nM). OBI-3424 exhibits potent cytotoxicity, in particular against cell lines derived from T-ALL with high AKR1C3 expression, with IC50 values in the low nM range[1].OBI-3424 also exerts potent cell killing against ALL PDXs, and the median IC50 values were 60.3 nM for B-ALL, 9.7 nM for T-ALL and 31.5 nM for ETP-ALL[1].
OBI-3424 (0.5-2.5 mg/kg; i.p.; once weekly; for 3 weeks) treatment induces regressions in PDXs mice and results in prolongation of mouse event-free survival[1].
[1]. Kathryn Evans, et al. OBI-3424, a Novel AKR1C3-Activated Prodrug, Exhibits Potent Efficacy against Preclinical Models of T-ALL. Clin Cancer Res. 2019 Jul 15;25(14):4493-4503.
Average Rating: 5 (Based on Reviews and 26 reference(s) in Google Scholar.)
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