P-3FAX-Neu5Ac |
| Katalog-Nr.GC50255 |
Sialic acid analog; sialyltransferase inhibitor
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 117405-58-0
Sample solution is provided at 25 µL, 10mM.
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Cell-permeable sialic acid analog. Deacetylation occurs intracellularly giving rise to a sialyltransferase inhibitor. Abolishes expression of SLex expression on HL-60 cells and reduces E-selectin and P-selectin binding. Prevents metastasis formation in a mouse lung metastasis model.
Rillahan et al (2012) Global metabolic inhibitors of sialyl- and fucosyltransferases remodel the glycome. Nat.Chem.Biol. 8 661 PMID:22683610 |Büll et al (2015) Targeted delivery of a sialic acid-blocking glycomimetic to cancer cells inhibits metastatic spread. ACS Nano. 9 733 PMID:25575241
Average Rating: 5 (Based on Reviews and 35 reference(s) in Google Scholar.)
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