Palmitoyl Serinol (Synonyms: C16-Serinol, S16) |
| Katalog-Nr.GC44548 |
2-Palmitoyl-Glycerol (2-PG) wurde zusammen mit dem potenten Endocannabinoid 2-Arachidonoyl-Glycerol (2-AG) aus verschiedenen Geweben isoliert.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 126127-31-9
Sample solution is provided at 25 µL, 10mM.
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2-Palmitoyl glycerol (2-PG) has been isolated along with the potent endocannabinoid 2-arachidonoyl glycerol (2-AG) from various tissues. Although 2-PG displays no intrinsic agonist activity on CB1 or CB2 receptors, it does potentiate the ability of 2-AG to inhibit adenylyl cyclase. 2-PG also potentiates the analgesic, hypokinetic, and anxiolytic effects of 2-AG in mice. This "entourage" effect has been attributed to the ability of compounds such as 2-PG to inhibit reuptake and/or compete with the active endocannabinoids for access to inactivating enzymes such as FAAH and monoglyceride lipase. Palmitoyl serinol is a stable analog of 2-PG bearing an amide linkage in place of the labile glyceryl ester. This has the potential to enhance its "entourage" activities as a result of a prolonged in vivo half-life. Palmitoyl serinol is also an analog of C-16 ceramide. Incubation of neuroblastoma cells with palmitoyl serinol causes apoptosis with an IC50 of approximately 80 µM.
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