PF-4693627 |
| Katalog-Nr.GC18700 |
PF-4693627 ist ein potenter, selektiver und oral bioverfÜgbarer mikrosomaler Prostaglandin-E-Synthase-1 (mPGES-1)-Inhibitor (IC50=3 nM) zur Behandlung von EntzÜndungen, die durch Osteoarthritis (OA) und rheumatoide Arthritis (RA) verursacht werden.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1312815-93-2
Sample solution is provided at 25 µL, 10mM.
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PF-4693627 is an orally bioavailable inhibitor of microsomal prostaglandin E (PGE) synthase-1 (mPGES-1; IC50 = 3 nM). It is selective for mPGES-1 over PGDS, TXAS, and 5-LO in HWB-1483 cells, which have IC50 values greater than 50 μM, as well as COX-2 in fetal fibroblasts (IC50 = >10 μM). PF-4693627 inhibits LPS-stimulated synthesis of PGE2 in human whole blood (IC50 = 109 nM). In vivo, PF-4693627 (10 mg/kg) inhibits PGE2 production in a guinea pig model of carrageenan-induced air pouch inflammation.
Review for PF-4693627
Average Rating: 5 (Based on Reviews and 40 reference(s) in Google Scholar.)
Review for PF-4693627
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