PI4KIIIbeta-IN-9 |
| Katalog-Nr.GC32847 |
PI4KIIIbeta-IN-9 ist ein potenter PI4KIIIβ-Inhibitor mit einem IC50 von 7 nM. PI4KIIIbeta-IN-9 hemmt auch PI3Kδ und PI3Kγ mit IC50-Werten von 152 nM bzw. 1046 nM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1429624-84-9
Sample solution is provided at 25 µL, 10mM.
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PI4KIIIbeta-IN-9 is a potent PI4KIIIβ inhibitor with an IC50 of 7 nM. PI4KIIIbeta-IN-9 also inhibits PI3Kδ and PI3Kγ with IC50s of 152 nM and 1046 nM, respectively.
PI4KIIIbeta-IN-9 (Compound 9) shows weak inhibition of PI3KC2γ (IC50 ~1 µM), PI3Kα (~2 µM), and PI4KIIIα (~2.6 µM) and <50% inhibition at concentrations up to 20 µM for PI4K2α, PI4K2β, and PI3Kβ. PI4KIIIbeta-IN-9 (Compound 9) forms a crescent shape that conforms to the active site of PI4KIIIβ. This molecule makes extensive contacts with PI4KIIIβ[1].
[1]. Rutaganira FU, et al. Design and Structural Characterization of Potent and Selective Inhibitors of Phosphatidylinositol 4 Kinase IIIβ. J Med Chem. 2016 Mar 10;59(5):1830-9.
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