Posenacaftor sodium (Synonyms: PTI-801 sodium) |
| Katalog-Nr.GC62522 |
Posenacaftor (PTI-801)-Natrium ist ein CFTR-Proteinmodulator (Cystic Fibrosis Transmembrane Regulator), der die Faltung und den Transport des CFTR-Proteins korrigiert.
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Cas No.: 2095064-06-3
Sample solution is provided at 25 µL, 10mM.
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Posenacaftor (PTI-801) sodium is a cystic fibrosis transmembrane regulator (CFTR) protein modulator that corrects the folding and trafficking of CFTR protein. Posenacaftor sodium is used for the research of cystic fibrosis (CF)[1].
Cystic fibrosis (CF) is an autosomal recessive disorder, caused by mutations of the cystic fibrosis transmembrane conductance regulator (CFTR)[1].CFTR is a cAMP-regulated chloride channel that is primarily located at the apical membrane of epithelial cells.Mutations in the CFTR gene lead to the production of a defective and misfolded CFTR protein, and impairs the flow of ions in and out of cells[1].Posenacaftor is a CFTR corrector, correctors are always designed to fix and restore the function of the defective CFTR protein. The corrected CFTR then moves to the cell surface, where it functions as a chloride channel and helps maintain the right balance of fluid in the airways[2].
[1]. Benjamin Kopp, et al. Compositions et procÉdÉs pour amÉliorer la fonction cftr dans des cellules affectÉes par la fibrose kystique. Patent WO2019156946.
[2]. Posenacaftor (PTI-801)
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