PSB-1115 (potassium salt) |
| Katalog-Nr.GC44733 |
PSB-1115 is an antagonist of the adenosine A2B receptor (Ki = 53.4 nM).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 409344-71-4
Sample solution is provided at 25 µL, 10mM.
PSB-1115 is an antagonist of the adenosine A2B receptor (Ki = 53.4 nM). [1] It is selective for A2B over A1 and A2A receptors, which have Ki values of 2,200 and 24,000 nM, respectively, and over the A3 receptor, which it inhibits only 14% at a concentration of 10 µM. PSB-1115 pre-treatment reduces relaxation of rat trachea induced by repeated dosing of the non-selective adenosine agonist NECA .[2]
Reference:
[1]. Hayallah, A.M., Sandoval-Ramírez, J., Reith, U., et al. 1,8-Disubstituted xanthine derivatives: Synthesis of potent A2B-selective adenosine receptor antagonists. J. Med. Chem. 45(7), 1500-1510 (2002).
[2]. Walaschewski, R., Begrow, F., and Verspohl, E.J. Impact and benefit of A2B-adenosine receptor agonists for the respiratory tract: Mucociliary clearance, ciliary beat frequency, trachea muscle tonus and cytokine release. J. Pharm. Pharmacol. 65(1), 123-132 (2013).
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