Quinacrine analog 34 |
| Katalog-Nr.GC44797 |
Quinacrine is a compound with multiple actions that is commonly used as an anti-protozoal agent.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1411646-44-0
Sample solution is provided at 25 µL, 10mM.
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Quinacrine is a compound with multiple actions that is commonly used as an anti-protozoal agent. It has also been shown to be a highly potent autophagy inhibitor, although the dose required to achieve this effect is considerably cytotoxic (LD50 = 2.5 µM). Quinacrine analog 34 is a derivative of quinacrine that was designed with an improved cell viability profile (LD50 = 27 µM) to inhibit autophagy. At a minimum concentration of 0.5 µM, this compound has been shown to increase the protein levels of the autophagy biomarker LC3-II and to induce lysosome deacidification.
Average Rating: 5 (Based on Reviews and 3 reference(s) in Google Scholar.)
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