R-IMPP (Synonyms: PF-00932239) |
| Katalog-Nr.GC32456 |
R-IMPP (PF-00932239) ist ein Anti-Sekretagogum von PCSK9 (IC50=4,8 μM), das auf das 80S-Ribosom abzielt, um die PCSK9-Proteintranslation zu hemmen.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2133832-83-2
Sample solution is provided at 25 µL, 10mM.
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R-IMPP is an inhibitor of PCSK9 secretion.
R-IMPP stimulates uptake of LDL-C in hepatoma cells by increasing LDL-R levels, without altering levels of secreted transferrin. R-IMPP does not decrease PCSK9 transcription or increase PCSK9 degradation, but causes transcript-dependent inhibition of PCSK9 translation. R-IMPP is able to selectively bind to human, but not E. coli, ribosomes[1].
[1]. Petersen DN, et al. A Small-Molecule Anti-secretagogue of PCSK9 Targets the 80S Ribosome to Inhibit PCSK9 Protein Translation. Cell Chem Biol. 2016 Nov 17;23(11):1362-1371
Average Rating: 5 (Based on Reviews and 31 reference(s) in Google Scholar.)
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