RAS/RAS-RAF-IN-1 |
| Katalog-Nr.GC62504 |
RAS/RAS-RAF-IN-1 ist ein potenter RAS- und RAS-RAF-Inhibitor. RAS/RAS-RAF-IN-1 hat eine KD von 5,0 μM-15 μM fÜr die BindungsaffinitÄt von Cyclophilin A (CYPA). RAS/RAS-RAF-IN-1 hat AntitumoraktivitÄt.
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Cas No.: 2447039-81-6
Sample solution is provided at 25 µL, 10mM.
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RAS/RAS-RAF-IN-1 is a potent RAS and RAS-RAF inhibitor. RAS/RAS-RAF-IN-1 has a KD of 5.0 μμ-15 μμ for cyclophilin A (CYPA) binding affinity. RAS/RAS-RAF-IN-1 has antitumor activity[1].
RAS/RAS-RAF-IN-1 (compound 89; for 4 hours) has an EC50 of 0.5 μμ-5.0 μμ for BRAF-GTP-KRAS-G12C disruption and has an IC50 of 1.0 μμ-10 μμ for pERK inhibition in H358 cells[1].
[1]. Meizhong Jin, et al. Compounds that participate in cooperative binding and uses thereof. WO2020132597A1.
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