Recombinant Human FAP (N-8His) (Synonyms: FAP; FAPA; DPPIV; SIMP; Fapalpha) |
Katalog-Nr.GC26394
One-Click Copy Product Info
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Recombinant Human Prolyl endopeptidase FAP is produced by our Mammalian expression system and the target gene encoding Leu26-Asp760 is expressed with a 8His tag at the N-terminus.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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FAP (also known as seprase) is a single-pass type II membrane protein which belongs to thepeptidase S9B family. FAP appears to act as a proteolytically active 170-kDa dimer, consisting of two 97-kDa subunits. It is a member of the group type II integral serine proteases, which includes dipeptidyl peptidase IV ( DPPIV / CD26 ) and related type II transmembrane prolyl serine peptidases, which exert their mechanisms of action on the cell surface. FAP is also an endopeptidase that can degrade Gelatin, Collagens I and IV, Fibronectin, and Laminin as well as several peptide hormones. The enzymatic activity is dependent on FAP association with DPPIV on the cell surface. The matrix-dedgrading activity of FAP contributes to tumor cell migration and invasion. In addition, FAP can enhance tumor cell growth by limiting the development of anti-tumor immunity.
| Purity | Greater than 93% as determined by SEC-HPLC. | Source | Mammalian expression system. |
| Phycical Appearance | Shipping Condition | ||
| Formulation | |||
Store at ≤-70°C, stable for 6 months after receipt.
Store at ≤-70°C, stable for 3 months under sterile conditions after opening.
Please minimize freeze-thaw cycles.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)