Chromatin/Epigenetics
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Epigenetics
Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.
Research Areas
- Bromodomain(44)
- Aurora Kinase(68)
- DNA Methyltransferase(41)
- HDAC(230)
- Histone Acetyltransferases(90)
- Histone Demethylases(110)
- Histone Methyltransferase(258)
- HIF(118)
- JAK(169)
- PARP(147)
- Pim(32)
- Protein Ser/Thr Phosphatases(23)
- RNA Polymerase(4)
- Sirtuin(80)
- Sphingosine Kinase-2(1)
- Polycomb repressive complex(2)
- SUMOylation(3)
- PAD(20)
- Epigenetic Reader Domain(269)
- MicroRNA(29)
- Protein Arginine Deiminase(15)
- Chromodomain(1)
- Citrullination(20)
- DNA/RNA Demethylation(2)
- DNA/RNA Methylation(8)
- Histone Deacetylation(43)
- Histones/Histone Peptides(62)
- PHD Domains(1)
- Tandem Tudor & Tudor-like Domains(1)
- PRMT(2)
- Readers(1)
- Small Interfering RNA (siRNA)(14)
- METTL3(4)
- WDR5(3)
- TET Protein(2)
- HuR(1)
- SF3B1(2)
Products Related to Chromatin/Epigenetics(1791)
- GC170551,2,3,4,5,6-HexabromocyclohexaneCAS: 1837-91-8Purity: >98%
Potently and directly inhibits JAK2 tyrosine kinase autophosphorylation, specifically inhibiting ligand-dependent JAK2 activation.
- GC17101SRT1720 HClCAS: 1001645-58-4Purity: >98.00%
SRT1720 HCl ist ein Aktivator von SIRT1(EC1.5 = 0.16 μM und maximale Aktivierung = 781%), einem NAD+-abhängigen Protein und Histon-Deacetylase, das wichtig in zahlreichen biologischen Prozessen ist.
- GC17126EX-527 R-enantiomerCAS: 848193-69-1Purity: >98.50%
EX-527 R-Enantiomer ((R)-EX-527) ist ein R-Enantiomer von Selisistat. Selisistat (EX-527) ist ein potenter und selektiver SIRT1-Inhibitor mit einem IC50-Wert von 98 nM.
- GC17162MK-5108 (VX-689)CAS: 1010085-13-8Purity: >98.00%
MK-5108 (VX-689) is a potent ATP-competitive inhibitor of Aurora A kinase with an IC 50 value of 0.064nM.
- GC17196HesperadinCAS: 422513-13-1Purity: >98.00%
Hesperadin is an ATP competitive indolinone inhibitor of Aurora B with an IC 50 of 250nM.
- GC17222GLPG0634 analogueCAS: 1206101-20-3Purity: >98.50%
Das GLPG0634-Analogon (Compoun 176) ist ein Breitband-JAK-Inhibitor mit IC50-Werten von < 100 nM gegen JAK1, JAK2 und JAK3.
- GC17284Anacardic acidCAS: 16611-84-0Purity: >98.00%
Anacardic acid, from cashew nut shell liquid, is a Histone acetyltransferase (HAT) inhibitor with IC 50 values of 8.5μM and 5μM for p300 and p300/CBP-associated factor (PCAF), respectively.
- GC17334EntacaponeCAS: 130929-57-6Purity: >98.00%
Entacapone is a potent, reversible, peripherally acting and orally active inhibitor of catechol-O-methyltransferase (COMT), which effectively inhibits rat liver total COMT with IC 50 and K i values of 20.1nM and 10.7nM, respectively.
- GC17472OxamflatinCAS: 151720-43-3Purity: >98.00%
Oxamflatin (Metacept-3) ist ein potenter HDAC-Inhibitor mit einem IC50 von 15,7 nM.
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC17023 | HLCL-61 | 1158279-20-9 | >99.50% | |
HLCL-61 ist ein erstklassiger Inhibitor der Protein-Arginin-Methyltransferase 5 (PRMT5). | ||||
| GC17050 | CYT387 | 1056634-68-4 | >98.50% | |
A potent inhibitor of JAK1 and JAK2 | ||||
| GC17055 | 1,2,3,4,5,6-Hexabromocyclohexane | 1837-91-8 | >98% | |
Potently and directly inhibits JAK2 tyrosine kinase autophosphorylation, specifically inhibiting ligand-dependent JAK2 activation. | ||||
| GC17073 | I-BET-762 | 1260907-17-2 | >99.00% | |
I-BET-762 (I-BET762; GSK525762) ist ein BET-BromodomÄnen-Inhibitor mit IC50 von 32,5-42,5 nM. | ||||
| GC17101 | SRT1720 HCl | 1001645-58-4 | >98.00% | |
SRT1720 HCl ist ein Aktivator von SIRT1(EC1.5 = 0.16 μM und maximale Aktivierung = 781%), einem NAD+-abhängigen Protein und Histon-Deacetylase, das wichtig in zahlreichen biologischen Prozessen ist. | ||||
| GC17118 | GSK J5 | 1394854-51-3 | >95.00% | |
inactive isomer of GSK J4, KDM inhibitor | ||||
| GC17126 | EX-527 R-enantiomer | 848193-69-1 | >98.50% | |
EX-527 R-Enantiomer ((R)-EX-527) ist ein R-Enantiomer von Selisistat. Selisistat (EX-527) ist ein potenter und selektiver SIRT1-Inhibitor mit einem IC50-Wert von 98 nM. | ||||
| GC17145 | SIRT1/2 Inhibitor IV | 14513-15-6 | - | |
SIRT1 and SIRT2 inhibitor | ||||
| GC17162 | MK-5108 (VX-689) | 1010085-13-8 | >98.00% | |
MK-5108 (VX-689) is a potent ATP-competitive inhibitor of Aurora A kinase with an IC 50 value of 0.064nM. | ||||
| GC17178 | TCS PIM-1 1 | 491871-58-0 | >98.00% | |
A Pim-1 kinase inhibitor | ||||
| GC17196 | Hesperadin | 422513-13-1 | >98.00% | |
Hesperadin is an ATP competitive indolinone inhibitor of Aurora B with an IC 50 of 250nM. | ||||
| GC17207 | UNC3866 | 1872382-47-2 | >98.00% | |
UNC3866 ist ein potenter Antagonist der CBX7-H3-Wechselwirkung, wie durch AlphaScreen bestimmt (IC50 = 66 ± 1,2 nM) und mehr als 100-fach selektiv fÜr CBX7 im Vergleich zu den anderen neun Mitgliedern dieses Methyl-Lysin (Kme)-Lesepanels. | ||||
| GC17222 | GLPG0634 analogue | 1206101-20-3 | >98.50% | |
Das GLPG0634-Analogon (Compoun 176) ist ein Breitband-JAK-Inhibitor mit IC50-Werten von < 100 nM gegen JAK1, JAK2 und JAK3. | ||||
| GC17241 | Thiolutin | 87-11-6 | >99.00% | |
An inhibitor of Hsp27 and RNA polymerases | ||||
| GC17275 | AMI-1 | 20324-87-2 | >98.00% | |
A cell permeable inhibitor of PRMTs | ||||
| GC17284 | Anacardic acid | 16611-84-0 | >98.00% | |
Anacardic acid, from cashew nut shell liquid, is a Histone acetyltransferase (HAT) inhibitor with IC 50 values of 8.5μM and 5μM for p300 and p300/CBP-associated factor (PCAF), respectively. | ||||
| GC17334 | Entacapone | 130929-57-6 | >98.00% | |
Entacapone is a potent, reversible, peripherally acting and orally active inhibitor of catechol-O-methyltransferase (COMT), which effectively inhibits rat liver total COMT with IC 50 and K i values of 20.1nM and 10.7nM, respectively. | ||||
| GC17344 | Alexidine dihydrochloride | 1715-30-6 | >99.00% | |
An alkyl bis(biguanide) antiseptic | ||||
| GC17358 | Octyl-α-ketoglutarate | 876150-14-0 | >95.00% | |
prolyl hydroxylases (PHD) activator | ||||
| GC17390 | Vorinostat (SAHA, MK0683) | 149647-78-9 | >99.00% | |
Ein HDAC-Inhibitor | ||||
| GC17405 | Chetomin | 1403-36-7 | >95.00% | |
Chetomin is a natural alkaloid derived from Chaetomium species, known for its significant anticancer and anti-inflammatory properties. | ||||
| GC17428 | SGI-110 | 929901-49-5 | >98% | |
| GC17455 | TAK-632 | 1228591-30-7 | >98.00% | |
A selective pan-Raf inhibitor | ||||
| GC17472 | Oxamflatin | 151720-43-3 | >98.00% | |
Oxamflatin (Metacept-3) ist ein potenter HDAC-Inhibitor mit einem IC50 von 15,7 nM. | ||||