Ribocil |
| Katalog-Nr.GC32103 |
Ribocil ist ein hochselektiver chemischer Modulator bakterieller Riboflavin-Riboschalter.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1381289-58-2
Sample solution is provided at 25 µL, 10mM.
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Ribocil is a highly selective chemical modulator of bacterial riboflavin riboswitches. Ribocil strongly inhibits GFP expression, achieving a 50% effective concentration (EC50) of 0.3 μM.Target: in vitro: Ribocil is a highly specific bioactive synthetic mimic of FMN, which competes with the natural ligand to inhibit FMN riboswitch-mediated expression of ribB and inhibits bacterial growth. Ribocil-B demonstrates superior microbiological activity as compared to Ribocil-A (minimum inhibitory concentration (MIC) = 1 μg/ml versus MIC ≥ 64 μg/ml), inhibition of riboflavin synthesis (IC50 = 0.13 μM versus IC50 > 26 μM), and binding affinity to the E. coli FMN aptamer (Kd = 6.6 nM versus Kd ≥ 10,000 nM).[1]
[1]. Howe JA, et al. Selective small-molecule inhibition of an RNA structural element. Nature. 2015 Oct 29;526(7575):672-7.
Average Rating: 5 (Based on Reviews and 14 reference(s) in Google Scholar.)
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