SBP-0636457 (Synonyms: SBI-0636457; SB1-0636457) |
Katalog-Nr.GC63870 |
SBP-0636457 (SB1-0636457) ist ein SMAC-Mimetikum und als IAP-Antagonist. SBP-0636457 bindet an die BIR-DomÄnen der IAP-Proteine mit einem Ki von 0,27 μM. SBP-0636457 kann fÜr die Erforschung von soliden Tumoren und hÄmatologischen Krebsarten verwendet werden.
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Cas No.: 1422180-49-1
Sample solution is provided at 25 µL, 10mM.
SBP-0636457 (SB1-0636457) is a SMAC mimetic, and as an IAP antagonist. SBP-0636457 binds to the BIR-domains of the IAP proteins, with a Ki of 0.27 μM. SBP-0636457 can be used for the research of solid tumors and hematologic cancers[1][2].
SBP-0636457 (1-20 μM) demonstrates no cytotoxicity in BT474, BT549, MCF7, and MDA-MB-231 breast cancer cell lines up to a concentration of 20μM[1].SBP-0636457 (10-1000 nM; 20 h) is ef?cacious as TRAIL-sensitizing agents in MDA-MB-231 cells, with an EC50 of 9 nM[1].
[1]. Finlay D, et, al. Small-molecule IAP antagonists sensitize cancer cells to TRAIL-induced apoptosis: roles of XIAP and cIAPs. Mol Cancer Ther. 2014 Jan; 13(1): 5-15.
[2]. Finlay D, et, al. Inducing death in tumor cells: roles of the inhibitor of apoptosis proteins. F1000Res. 2017 Apr 27; 6:587.
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