SM-433 |
| Katalog-Nr.GC63195 |
SM-433, ein Smac-Mimetikum, fungiert als Inhibitor des Inhibitors von Apoptoseproteinen (IAPs). SM-433 weist eine starke BindungsaffinitÄt zum XIAP BIR3-Protein mit einem IC50 < 1 μM auf (Patent WO2008128171A2).
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Cas No.: 1071992-81-8
Sample solution is provided at 25 µL, 10mM.
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SM-433, a Smac mimetic, function as inhibitor of inhibitor of apoptosis proteins (IAPs). SM-433 exhibits strong binding affinity XIAP BIR3 protein with an IC50<1 μM. (patent WO2008128171A2)[1].
SM-433 exhibits strong inhibitory activity against MDA-MB -2131 human breast cancer cells and SK-OV-3 ovarian cancer cells (IC50s<10 μM, respectively)[1].
[1]. Shaomeng Wang, et al. Diazo bicyclic smac mimetics and the uses thereof. WO2008128171A2.
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