Sphingosine-d7 (d18:1) (Synonyms: (-)-Sphingosine-d7, D-erythro-Sphingosine C-18-d7) |
| Katalog-Nr.GC40104 |
Sphingosin-d7 (d18:1) (Erythrosphingosin-d7) ist das mit Deuterium markierte D-erythro-Sphingosin. D-erythro-Sphingosin (Erythrosphingosin) ist ein sehr potenter Aktivator der p32-Kinase mit einem EC50 von 8 μM und hemmt die Proteinkinase C (PKC). D-erythro-Sphingosin (Erythrosphingosin) ist ebenfalls ein PP2A-Aktivator.
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Cas No.: 1246304-34-6
Sample solution is provided at 25 µL, 10mM.
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Sphingosine-d7 (d18:1) is intended for use as an internal standard for the quantification of sphingosine (d18:1) by GC- or LC-MS. Sphingosine (d18:1) is formed primarily from the breakdown of ceramide. Sphingosine (d18:1) inhibits protein kinase C and phosphatidic acid phosphohydrolase, whereas it activates phospholipase D and diacylglycerol (DAG) kinase. Phosphorylation of sphingosine (d18:1) by sphingosine kinases 1 and 2 (SPHK1, SPHK2) produces sphingosine-1-phosphate, a potent bioactive lipid that exhibits a broad spectrum of biological activities including cell proliferation, survival, migration, cytoskeletal organization, and morphogenesis.
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