Tenofovir diphosphate |
| Katalog-Nr.GC60357 |
Tenofovirdiphosphat (TFV-DP) ist ein kompetitiver DNA-Polymerase-Inhibitor (in Bezug auf dATP) und ein Substrat der reversen Transkriptase (RT) von HIV Typ 1 (HIV-1).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 166403-66-3
Sample solution is provided at 25 µL, 10mM.
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Tenofovir diphosphate (TFV-DP) is a competitive DNA polymerases inhibitor (with respect to dATP) and a substrate of HIV type 1 (HIV-1) reverse transcriptase (RT)[1].
Tenofovir diphosphate acts as an inhibitor of DNA pol. Tenofovir-diphosphate is a weak inhibitor of DNA polymerases (pol) α, δ, and ?, with values for the Ki for PMPApp (PMPAppKi) relative to the Km for dATP (dATPKm) of 10.2, 10.2, and 15.6, respectively[1].
[1]. Gabriel Birkus, et al. Tenofovir Diphosphate Is a Poor Substrate and a Weak Inhibitor of Rat DNA Polymerases Alpha, Delta, and epsilon. Antimicrob Agents Chemother. 2002 May;46(5):1610-3.
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