Chitin |
Catalog No.GB57663
One-Click Copy Product Info
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Chitin est une variété de sucres extraits des coquilles de crustacés marins et est largement présente dans les crevettes et les crabes dans la nature.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1398-61-4
Sample solution is provided at 25 µL, 10mM.
Chitin est une variété de sucres extraits des coquilles de crustacés marins et est largement présente dans les crevettes et les crabes dans la nature[1]. Chitin est un polysaccharide linéaire du sucre aminé N-acétylglucosamine et est présente dans la matrice extracellulaire de divers invertébrés (comprendre les éponges, les mollusques, les nématodese et les arthropodes, ainsi que les champignons)[2]. La structure de chitin est comparable à celle de la cellulose, formant des nanofibrilles cristallines ou des ''whiskers'' (moustaches cristallines), et est fonctionnellement comparable à la protéine kératine[3]. Chitin est un régulateur taille-dépendant pour la production de TNF (facteur de nécrose tumorale) et d' IL-10 (interleukine 10) des macrophages[4]. Chitin peut induire la polarisation des macrophages M2 in vivo au moyen d'activer les voies de signalisation des récepteurs TLR2 et Dectin-1, tout en favorisant les réponses anti-inflammatoires et de réparation tissulaire[5]. Chitin peut induire les fibroblastes à libérer l'interleukine-8 (IL-8), qui est impliquée dans la migration et la prolifération des fibroblastes et des cellules endothéliales vasculaires[6].
References:
[1] Arbia W, Arbia L, Adour L, et al. Chitin extraction from crustacean shells using biological methods–a review[J]. Food Technology and Biotechnology, 2013, 51(1): 12-25.
[2] Moussian B. Chitin: Structure, chemistry and biology[J]. Targeting chitin-containing organisms, 2019: 5-18.
[3] Ifuku S, Saimoto H. Chitin nanofibers: preparations, modifications, and applications[J]. Nanoscale, 2012, 4(11): 3308-3318.
[4] Da Silva C A, Chalouni C, Williams A, et al. Chitin is a size-dependent regulator of macrophage TNF and IL-10 production[J]. The Journal of immunology, 2009, 182(6): 3573-3582.
[5] Lee C G, Da Silva C A, Dela Cruz C S, et al. Role of chitin and chitinase/chitinase-like proteins in inflammation, tissue remodeling, and injury[J]. Annual review of physiology, 2011, 73(1): 479-501.
[6] Okamoto Y, Watanabe M, Miyatake K, et al. Effects of chitin/chitosan and their oligomers/monomers on migrations of fibroblasts and vascular endothelium[J]. Biomaterials, 2002, 23(9): 1975-1979.
| Cas No. | 1398-61-4 | SDF | |
| Formula | (C8H13NO5 )n | M.Wt | |
| Solubility | Storage | Store at RT | |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)