Chitin |
Catalog No.GB57663
One-Click Copy Product Info
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Chitin은 해양 갑각류의 껍질에서 추출된 다양한 설당의 일종이고 자연계의 새우와 게에서 널리 발견된다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1398-61-4
Sample solution is provided at 25 µL, 10mM.
Chitin은 해양 갑각류의 껍질에서 추출된 다양한 설당의 일종이고 자연계의 새우와 게에서 널리 발견된다. Chitin은 아미노당 N-acetylglucosamine의 선형 다당류이고 스펀지, 연체동물, 선충류, 절지동물 등 다양한 무척추동물의 세포외 기질뿐만 아니라 곰팡이에도 존재한다[2]. Chitin의 구조는 섬유소와 유사해서 결정성 나노섬유나 털 모양을 이루고 기능적으로는 케라틴과 비교할 수 있다[3]. Chitin은 크기 의존적으로 대식세포의 TNF와 IL-10 생성을 조절하는 인자이다[4]. Chitin은 TLR2와 Dectin-1 수용체 신호전달 경로를 활성화해서 체내 실험에서 M2 대식세포 분화를 유도하고 항염증 및 조직 수리 반응을 촉진한다[5]. Chitin은 섬유아세포가 인터루킨-8(IL-8)을 방출하도록 유도하는데 섬유아세포와 혈관내피세포의 이동과 증식에 관여한다[6].
References:
[1] Arbia W, Arbia L, Adour L, et al. Chitin extraction from crustacean shells using biological methods–a review[J]. Food Technology and Biotechnology, 2013, 51(1): 12-25.
[2] Moussian B. Chitin: Structure, chemistry and biology[J]. Targeting chitin-containing organisms, 2019: 5-18.
[3] Ifuku S, Saimoto H. Chitin nanofibers: preparations, modifications, and applications[J]. Nanoscale, 2012, 4(11): 3308-3318.
[4] Da Silva C A, Chalouni C, Williams A, et al. Chitin is a size-dependent regulator of macrophage TNF and IL-10 production[J]. The Journal of immunology, 2009, 182(6): 3573-3582.
[5] Lee C G, Da Silva C A, Dela Cruz C S, et al. Role of chitin and chitinase/chitinase-like proteins in inflammation, tissue remodeling, and injury[J]. Annual review of physiology, 2011, 73(1): 479-501.
[6] Okamoto Y, Watanabe M, Miyatake K, et al. Effects of chitin/chitosan and their oligomers/monomers on migrations of fibroblasts and vascular endothelium[J]. Biomaterials, 2002, 23(9): 1975-1979.
| Cas No. | 1398-61-4 | SDF | |
| Formula | (C8H13NO5 )n | M.Wt | |
| Solubility | Storage | Store at RT | |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)