Crustacean Cardioactive Peptide CCAP |
| Catalog No.GC33690 |
Crustacean Cardioactive Peptide CCAP est un nonapeptide cyclique amidé hautement conservé, isolé pour la première fois des organes péricardiques du crabe de rivage Carcinus maenas, où il joue un rôle dans la régulation du rythme cardiaque ; Crustacean Cardioactive Peptide CCAP module également l'activité neuronale chez d'autres arthropodes.
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Cas No.: 309247-84-5
Sample solution is provided at 25 µL, 10mM.
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Crustacean Cardioactive Peptide (CCAP) is a highly conserved, amidated cyclic nonapeptide, first isolated from the pericardial organs of the shore crab Carcinus maenas, where it has a role in regulating heartbeat; Crustacean Cardioactive Peptide (CCAP) also modulates the neuronal activity in other arthropods.
Ultrabithorax and Abdominal-A are not necessary for specification of the CCAP-interneurons, but are absolutely required to prevent the death by apoptosis of the CCAP-efferent neurons[2].
CCAP, FMRFamide and SALDKNFMRFamide increase the mosquito antennal accessory pulsatile organ (APO) and heart contraction rates, increase hemolymph flow velocity in the antennal space[1].
[1]. Suggs JM, et al. CCAP and FMRFamide-like peptides accelerate the contraction rate of the antennal accessory pulsatile organs (auxiliary hearts) of mosquitoes. J Exp Biol. 2016 Aug 1;219(Pt 15):2388-95. [2]. Moris-Sanz M, et al. The study of the Bithorax-complex genes in patterning CCAP neurons reveals a temporal control of neuronal differentiation by Abd-B. Biol Open. 2015 Aug 14;4(9):1132-42.
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